Hidden File Finder is a compact tool which can easily locate and display the hidden files on your PC, which may be useful if you're looking for malware.
Operation is fairly straightforward: point the program at your starting folder, or the entire system; click "Start Scan", and then watch as the program lists anything of interest. (It won't take long: our test PC saw around 36,000 folders 220,000 files checked in under a minute.)
Once the scan has finished, you'll be presented with a report which includes each hidden file and its name, type, size, creation date and path. This can be sorted by each attribute, too, so you can easily pick out the largest files, or those created most recently. And to help further, the program highlights executable files in red, while ignoring hidden files of known types (desktop.ini, thumbs.db) entirely.
If you do spot anything which looks suspect, right-clicking it provides options to check the file at VirusTotal, search for it on Google, unhide the file or delete it entirely. Though the latter option is probably best avoided unless you're very, very sure that it's safe to be removed.
Please note, Hidden File Finder attempted to install two toolbars on our PC, along with its own code. Pay close attention during installation.
If you'd like to run the program from a USB key, though, that's possible, too. Install it first, then simply copy the program folder to whatever mobile drive you'd like to use.